CARDIOVASCULAR KIDNEY METABOLIC SYNDROME (CKM).
NOVAPEP IS MODIFYING NVP-202 TO PRODUCE NOVEL PEPTIDE ANALOGS WITH SIGNIFICANTLY IMPROVED CIRCULATING HALF-LIFE - THE NVP-300 SERIES.
NVP-300 Series Lead Candidate in Cardiovascular Kidney Metabolic Syndrome
The Lead NVP-300 Candidate will be progressed into a Phase 1 Trial in 2027.
COLITIS PROGRAM
APC has been shown to be effective in vivo in diabetic kidney disease and diabetes-induced atherosclerosis:
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Activated Protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. Isermann et al, Nature Medicine, 2007.
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Activated Protein C Targets PI3K-p85/XBP1 Pathway to Inhibit Hyperglycemia Induced Endoplasmic Reticulum Stress in Diabetic Nephropathy.' Isermann et al, Blood, 2012.
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Integrin Alphav-beta3 on Podocytes Orchestrates Coagulation Protease Signaling through Protease-Activated Receptors. Madhusudhan et al, Blood, 2017.
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Diabetic kidney disease: as easy as aPC? MacFadyen et al, Blood, 2017.
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Cytoprotective Activated Protein C averts Nlrp3 inflammasome induced ischemia-reperfusion injury via mTORC1 inhibition.’ Nazir et al, Blood, 2017.
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Activated protein C reverses epigenetically sustained p66Shc expression in plaque-associated macrophages in diabetes. Shahzad et al, Commun Biol, 2018.
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Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular P21 expression. Al-Dabet et al. Nature Coms, 2022.
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Thrombosis and Inflammation - A Dynamic Interplay and the Role of Glycosaminoglycans and Activated Protein C Kohli et al, Front. Cardiovasc. Med, 2022.
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Activated protein C ameliorates diabetes-induced atherosclerosis by sustaining macrophage efferocytosis. Ambreen et al. Cardiovasc Diabetol, 2025.